The biggest danger you’re going to run into is that those distros all lie downstream of the real changes, so non-gaming (and potentially security related) fixes might be slow or incompatible.

If you go with something like Fedora or Ubuntu, there is going to be full support on all the core things, and you can build the gaming experience you want on top. Any changes that Nobara or Drauger are making to their distros you could probably make yourself.

(I’ve never used any of those distros, but I’ve found winehq and other tools on Fedora more than sufficient)